Choroid plexus cyst (CPC)

  • Choroid plexus represents a network of specialized cells found in the ventricles of the fetal brain, which produce cerebrospinal fluid;
  • Sometimes during the antenatal period, a cystic structure is found within the choroid plexus of the lateral ventricles of the fetal brain and this is called choroid plexus cyst (CPC). It can be on one side (unilateral) or both sides (bilateral);
  • During a mid-trimester ultrasound, CPC can be found in ~2-5% of the normal fetuses. Almost all of these cysts will disappear in the subsequent part of the pregnancy. The CPC itself carries no clinical sequelae after birth whether it regresses or not;
  • However, there is a weak association between CPC with Edwards syndrome and Downs syndrome;
  • It is important to have a fetal morphology scan to look for any additional ultrasound markers for chromosomal abnormalities;
  • For isolated CPC (i.e. no other ultrasound markers for chromosomal abnormalities), antenatal screening with OSCAR or NIPT test is considered adequate. An amniocentesis is not advised, unless the couple wants a 100% certainty on the fetal karyotype.
This article is contributed by Dr. T.N. Danny Leung
updated on 25.09.2020