- The condition of AMC can be due to abnormal fibrosis of the muscle tissue causing muscle shortening, and therefore the lack of active extension and flexion in the affected joints
- There are many potential causes for AMC, including molecular, muscular and connective tissue development disorders as well as neurological abnormalities. There might be syndromic causes as well
- Consider amniocentesis for chromosomal anomalies as well some genetic abnormalities. However, a normal karyotyping or array CGH results from the amniotic fluid cannot exclude all underlying conditions such as neurological, connective tissue or even syndromic disorders
- Postnatal surgery was required to enhance the joint mobility and function but the joint contracture might not be completely cured despite postnatal treatment and surgery
